Funded Startups in Alabama
Birmingham accounts for the majority of the 50 most recent funded Alabama companies in this dataset, with rounds ranging from $10K community grants to Flee…
Birmingham accounts for the majority of the 50 most recent funded Alabama companies in this dataset, with rounds ranging from $10K community grants to Fleetio's $450M Series D in March 2025. The city's activity spans biotechnology (Yuva Biosciences, Acclinate, Endomimetics), artificial intelligence (ArcheHealth, QuantHUB, Analytical AI), and health care, with Medical Properties Trust's $804M round in May 2024 representing the largest single disclosed raise in the set.
Huntsville forms a distinct secondary cluster anchored by defense and government contractors — Performance Drone Works and Tango Tango both raised in mid-2025 — alongside AI firms Sentar and Archarithms. Rounds outside these two cities appear in Mobile (OPē Technologies, $6M hardware round in August 2025), Vestavia Hills (Rampart IC, $17M in May 2025), and Tuscaloosa (City Detect, $2M Seed in September 2024). Across the full set, the majority of rounds carry a Series Unknown classification, with eight labeled Seeds and two Series A rounds — Rise in November 2024 and Acclinate in May 2024 — among the few with explicit stage designations.
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Frequently asked
What are the largest recent rounds among Alabama-funded companies?
Medical Properties Trust ($804M, May 2024), Fleetio ($450M Series D, March 2025), and Landing ($180M, May 2025) are the three largest disclosed raises in this dataset. Rampart IC ($17M, May 2025) and Evernest ($15M, January 2025) represent the next tier, both Birmingham-based.
Which Alabama cities have the most funded startup activity?
Birmingham is by far the most active city in this 50-company set, with companies spanning biotech, AI, health care, software, and real estate. Huntsville is the clear second, concentrated in government/military technology and AI. A handful of rounds appear in Mobile, Vestavia Hills, Tuscaloosa, and Florence, but activity outside the two main hubs is sparse.
Which sectors are most represented among recently funded Alabama startups?
Biotechnology appears most frequently, with Yuva Biosciences, Acclinate, Endomimetics, Serina Therapeutics, ResBiotic, TIXiMED, and Southern Research all raising between late 2023 and early 2025. Artificial intelligence is the second most common sector, and health care rounds out the top three, anchored by companies such as Rampart IC and Medical Properties Trust.
Does Huntsville have a distinct defense-technology funding cluster?
Yes. Performance Drone Works (Government and Military, July 2025) and Tango Tango ($6M, Government and Military, May 2025) are both Huntsville-based. The city also houses hardware startup Yard Robotics, consumer electronics firm Quoherent, and AI companies Sentar and Archarithms — a profile noticeably distinct from Birmingham's biotech and commerce concentration.
What round stages are most common for Alabama startups in this data?
The majority of the 50 rounds are classified as Series Unknown, limiting stage-level analysis. Eight rounds carry a Seed label, including ArcheHealth ($7M), Yuva Biosciences ($8M), and Overworld ($10M). Only three rounds have explicit later-stage designations: Series A rounds for Rise (November 2024) and Acclinate (May 2024), and Fleetio's Series D (March 2025).
Are there Alabama startups raising very small rounds — under $100K?
Several companies in the dataset raised amounts well below $100K: Urban Ministry ($10K), Curtiss Motorcycle Company ($20K), Aletheia House ($30K), Nyad ($30K), and Croux ($50K). These sit alongside nine-figure raises in the same geographic market, pointing to a wide funding spectrum that includes grants and early angel capital alongside institutional venture rounds.
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