Funded Artificial Intelligence Startups in Portland
The ten AI companies listed here represent funded activity in Portland from February 2021 through July 2025, with eight headquartered in Portland, Oregon a…
The ten AI companies listed here represent funded activity in Portland from February 2021 through July 2025, with eight headquartered in Portland, Oregon and two — RxAnte and KinoTek — based in Portland, Maine. Early-stage rounds dominate: four Seed deals and two Pre-Seed rounds account for six of the ten entries, including the two most recent closes — Regulate's undisclosed Seed in July 2025 and Stitch Studio's undisclosed Pre-Seed in April 2025.
Disclosed round sizes span a wide range, from KinoTek's $600K Pre-Seed in February 2021 to Aisles' $30M Series A in May 2024 — the largest single raise in this set. Three rounds (Regulate, Stitch Studio, UMU) list undisclosed amounts, meaning aggregate capital figures undercount total investment. Application areas include healthcare AI (First Ascent Biomedical, Rewire Neuro), enterprise learning (UMU), grocery and retail software (Aisles), and home services (Shelpful).
Most recent rounds
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Frequently asked
What is the largest disclosed round among Portland AI startups in this set?
Aisles leads with a $30M Series A closed in May 2024, making it the only disclosed eight-figure raise in this group. The next largest is RxAnte's $15M (Series Unknown, December 2022, Portland, Maine), followed by First Ascent Biomedical's $6M Seed from January 2025.
Do these companies span Portland, Oregon and Portland, Maine, or just one?
Both cities appear. Eight of the ten companies are headquartered in Portland, Oregon. The two exceptions are RxAnte ($15M, December 2022) and KinoTek ($600K Pre-Seed, February 2021), both based in Portland, Maine.
What funding stages dominate this segment?
Early-stage rounds account for the majority — four Seed rounds and two Pre-Seed rounds make up six of the ten entries. The remaining four span Series A (Aisles), Series C (UMU), Series Unknown (RxAnte), and one additional Seed. No Series B is present in this set.
How recent is funding activity for Portland AI companies?
The two most recent rounds closed in 2025 — Regulate raised an undisclosed Seed in July 2025, and Stitch Studio closed an undisclosed Pre-Seed in April 2025. Before that, First Ascent Biomedical's $6M Seed in January 2025 and Sightglass's $3M Seed in December 2024 mark a cluster of late-2024 to mid-2025 activity.
Which verticals do these AI companies operate in?
Healthcare and life sciences appear in at least two companies — First Ascent Biomedical and Rewire Neuro (neurology, $2M Seed, September 2021). Other represented areas include enterprise learning (UMU, Series C), retail and grocery software (Aisles, $30M Series A), home services (Shelpful, $3M Seed), and creative tooling (Stitch Studio).
How many rounds in this set have undisclosed amounts, and what do the disclosed rounds sum to?
Three rounds list undisclosed amounts: Regulate, Stitch Studio, and UMU. The seven rounds with disclosed figures — ranging from KinoTek's $600K Pre-Seed to Aisles' $30M Series A — sum to approximately $59.6M across this set of ten companies.
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