Funded Artificial Intelligence Startups in San Diego
The 35 companies in this dataset raised capital between January 2021 and November 2025, spanning verticals from defense autonomy and computational drug dis…
The 35 companies in this dataset raised capital between January 2021 and November 2025, spanning verticals from defense autonomy and computational drug discovery to robotics, fleet safety, and sales enablement. The largest disclosed round is Seismic's $170M Series G (August 2021), followed by Iambic Therapeutics' $100M venture round (November 2025) and Netradyne's $65M debt financing (September 2022). Shield AI's $60M Series E (December 2022) and Kneron's $49M Series B (September 2023) round out the top five by disclosed capital.
Early-stage activity has continued into 2025, with Magier AI ($100K pre-seed, May 2025) and Self Inspection ($3M seed, February 2025) among recent closes. Round structures across the full set are varied — debt financing, corporate rounds, equity crowdfunding, and grants all appear alongside conventional venture stages — reflecting a San Diego ecosystem shaped by its defense contracting and life sciences base as much as by general-purpose AI infrastructure.
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Frequently asked
What are the largest disclosed rounds in this dataset?
Seismic's $170M Series G (August 2021) is the largest single raise shown. Iambic Therapeutics followed with a $100M venture round in November 2025, and Netradyne secured $65M via debt financing in September 2022. Shield AI's $60M Series E (December 2022) and Kneron's $49M Series B (September 2023) complete the top five by disclosed amount.
How does 2024–2025 activity compare to earlier years in the set?
Nine companies closed rounds in 2024 — including Brain Corp ($32M, February 2024) and Ainos ($9M, May 2024) — and six have raised in 2025 through November, headlined by Iambic Therapeutics' $100M round. The larger disclosed raises are concentrated in 2021–2022, when Seismic ($170M), Netradyne ($65M), and Shield AI ($60M) all closed.
What sectors do these San Diego AI companies operate in?
The dataset covers defense autonomy (Shield AI), computational drug discovery (Iambic Therapeutics, Sinopia Biosciences, Persephone Biosciences), autonomous robotics (Brain Corp), fleet driver safety (Netradyne), sales enablement (Seismic), edge AI chips (Kneron), and financial tools (Mosaic.tech, Blooma, Hedgedesk). The density of life sciences and defense-adjacent names reflects San Diego's established base in both industries.
Which round stages appear most often?
"Series Unknown" rounds — including those tagged "Venture - Series Unknown" — account for the largest group, covering companies such as Brain Corp, Ainos, Gretel, and Soaak Technologies. Eight companies raised labeled seed rounds. Pre-seed appears for three companies: Magier AI ($100K), AetherLab, and Chateauz ($160K).
Which companies have reached Series B or later?
Three companies have closed rounds at Series B or higher: Kneron (Series B, $49M, September 2023), Shield AI (Series E, $60M, December 2022), and Seismic (Series G, $170M, August 2021). Iambic Therapeutics and Netradyne each raised large sums — $100M and $65M respectively — under labels that do not specify a series letter.
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