Series B Funded Startups in Italy
Across these 22 Series B rounds in Italy, the largest disclosed amount is AAVantgarde Bio’s $141M (2025-11-03).
Across these 22 Series B rounds in Italy, the largest disclosed amount is AAVantgarde Bio’s $141M (2025-11-03). That round dwarfs the rest of the disclosed figures: only MMI reaches $75M (2022-07-20), and nearly all other disclosed rounds cluster well below $40M (for example, Caracol at $40M on 2025-10-15; Le av Space at $22M on 2023-07-25; W•SENSE at $8M on 2025-04-15). The only undisclosed rounds appear twice (CrescItalia on 2023-01-01 and Isplora.com on 2022-05-20), so comparisons above rely on disclosed amounts only.
Geographically, the list concentrates in northern Italy’s cities: 10 of 22 rows are based in Milano/Milan (including AAVantgarde Bio on 2025-11-03 and Artemest on 2022-05-03), with Lombardia also recurring via multiple cities (e.g., MMI in Pisa is in Toscana, while Caracol is in Lombardia). Temporally, rounds span from 2021-02-16 (Inxpect) through 2025-11-03, with several entries packed into 2022 and 2023 (e.g., five rounds in 2022-05 alone: Artemest $16M, Scalapay $27M, and two additional entries with matching dates aside from undisclosed amounts). Sector-wise, Biotechnology appears repeatedly (AAVantgarde Bio $141M; Kither Biotech $20M on 2022-03-16), while Energy also shows up multiple times ($17M Energy Dome on 2023-07-20; $10M Tau Group on 2023-02-01; $6M Enerbrain on 2021-08-02).
Most recent rounds
22 shownRelated listings
Frequently asked
What stands out about the largest disclosed Series B round in Italy, and how far above the rest is it?
AAVantgarde Bio’s disclosed $141M (2025-11-03) is the only round above $75M disclosed in this list; the next-largest disclosed amount is MMI’s $75M (2022-07-20). Most other disclosed rounds sit in the $20M–$40M band, such as Caracol at $40M (2025-10-15) and Poke House at $24M (2021-04-20).
Are Series B rounds clustered around specific time windows within the shown period?
Dates run from 2021-02-16 (Inxpect) to 2025-11-03 (AAVantgarde Bio), but there is noticeable density around mid-2022: Artemest closed on 2022-05-03 for $16M and Scalapay closed the same day for $27M. Another tight grouping appears in 2023-07, with Leaf Space at $22M (2023-07-25) and Energy Dome at $17M (2023-07-20).
Which sectors appear most consistently, and do they include any of the biggest rounds?
Biotechnology is represented more than once, including AAVantgarde Bio ($141M, 2025-11-03) and Kither Biotech ($20M, 2022-03-16). Energy also recurs across multiple entries—Energy Dome ($17M, 2023-07-20), Tau Group ($10M, 2023-02-01), and Enerbrain ($6M, 2021-08-02)—but its disclosed amounts generally fall below the largest biotech figure.
Do any single cities dominate the geography of these Series B rounds?
Milano/Milan is the most frequent location in this set, appearing on multiple rows such as AAVantgarde Bio ($141M, 2025-11-03), Artemest ($16M, 2022-05-03), and Poke House ($24M, 2021-04-20). Beyond that, other cities are present but less concentrated—for example, Rome appears with Cyber Guru ($25M, 2024-10-24) and Exein ($16M, 2024-07-12), while Torino appears with Tau Group ($10M, 2023-02-01) and Enerbrain ($6M, 2021-08-02).
Are there outliers to investigate, either by unusually large or unusually small disclosed amounts?
Yes: the upper-tail outlier is AAVantgarde Bio at $141M (2025-11-03), while the lowest disclosed amount is Enerbrain at $6M (2021-08-02). Near the bottom, W•SENSE is also small at $8M (2025-04-15) and Tau Group is $10M (2023-02-01), both well below mid-range rounds like Scalapay’s $27M (2022-05-03) or Caracol’s $40M (2025-10-15).
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