Karyopharm Therapeutics: Funding, Investors & Team (Sep 2026)

Karyopharm Therapeutics Inc. (Nasdaq: KPTI) is an innovation-driven pharmaceutical company dedicated to the discovery, development, and commercialization of novel first-in-class drugs directed against nuclear export and related targets for the treatment of cancer and other major diseases. Karyopharm's Selective Inhibitor of Nuclear Export (SINE) compounds function by binding with and inhibiting the nuclear export protein XPO1 (or CRM1). Karyopharm’s lead compound, XPOVIO® (selinexor), received accelerated approval from the U.S. Food and Drug Administration (FDA) in July 2019 in combination with dexamethasone as a treatment for patients with heavily pretreated multiple myeloma. In June 2020, XPOVIO was approved by the FDA as a treatment for patients with relapsed or refractory diffuse large B-cell lymphoma. A Marketing Authorization Application for selinexor for patients with heavily pretreated multiple myeloma is also currently under review by the European Medicines Agency. In addition to single-agent and combination activity against a variety of human cancers, SINE compounds have also shown biological activity in models of neurodegeneration, inflammation, autoimmune disease, certain viruses and wound-healing. Karyopharm has several investigational programs in clinical or preclinical development.

Karyopharm Therapeutics has raised $165M across 1 round on record. The most recent is an undisclosed round of $165M announced in Dec 2022.

Karyopharm Therapeutics' most recent funding round on record is an undisclosed round of $165M, announced in Dec 2022.

FundedIQ lists Sharon Shacham (Founder) at Karyopharm Therapeutics.

Karyopharm Therapeutics is based in Newton, Massachusetts, United States.

Karyopharm Therapeutics is in the 251-500 employee band.

Karyopharm Therapeutics' latest round of $165M is above the $4.8M median round size for Health Care companies on FundedIQ across 3,653 tracked companies over the last two years.